Prescription and operational guidelines for INHD are presented here. Prescription guidelines. While the prescription parameters detailed in literature have minor variations, they are reasonably consistent. In addition, an acceptable range for nocturnal dialysis prescriptions is shown below. This guidance has been produced in collaboration with the UK Kidney Patient Safety Committee, to summarise known safety issues with dialysis and CRRT and describe what to do to minimise or prevent Modalities include continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD). This topic reviews the peritoneal dialysis prescription, including the optimal amount of delivered dialysis, for both modalities. The evaluation of decreased solute clearance and ultrafiltration are discussed elsewhere. The International Society of Peritoneal Dialysis (ISPD) has recently published Guidelines for PD in AKI in an attempt to address the issue of the optimal dialysis dose when using PD to treat this condition. In this sense, many studies evaluating the PD use in AKI patients used weekly urea Kt/V to assess the delivered dialysis dose. The guideline on measurement of renal function states: Guideline I.1.1. Renal function should not be estimated from measurements of blood urea or creatinine alone. Cockcroft and Gault equation or reciprocal creatinine plots should not be used when the GFR is <30 mL/min or to determine the need for dialysis. Guideline I.1.3 The dialysis solution sodium level in the sample prescription is 145 mM. This level is generally acceptable for patients who have normal or slightly reduced predialysis serum sodium concentrations. If marked predialysis hypernatremia or hyponatremia is present, the dialysis solution sodium level will have to be adjusted accordingly. a. The guidelines have been published in the Journal of the International Society for Peritoneal Dialysis. This guideline has been written with the focus on the person doing PD. It is proposed that dialysis delivery should be 'goal-directed'. there may be a quality of life benefit from a modified dialysis prescription to minimize the burden of Principles of prescribing. Renal impairment reduces the clearance of some drugs. 4 When prescribing for patients on dialysis, it is essential to consult a reference guide ( Box) to determine if the drug is subject to renal clearance and requires a dose adjustment. Given the paucity of large pharmacokinetic studies, dosing recommendations often •Adequacy targets for dialysis should include both solute and fluid removal. •The minimum target for combined renal and peritoneal target for small solute clearance is: •Kt/V urea = 1.7/ Week If your unit refers to CSN guidelines or NKF KDOQI guidelines. 3, 41 - A separate target for creatinine clearance is not required in CAPD. The typical APD prescription should take into account the following factors: 1. Absence or presence of daytime dwell 2. Dwell volume (1500 - 2000mL is the typical starting volume; larger patients National Center for Biotechnology Information National Center for Biotechnology Information These patients may benefit from prescription changes and/or modality switch. (1B) 5. Peritoneal Dialysis (PD) (Guidelines PD 5.1 - 5.2) Guideline 5.1 - PD : Infectious Complications Guideline 5.1.1 - PD Infectious Complications : Prevention Strategies This guideline is written primarily for doctors and nurses working in dia