Abstract. Chordoma is a rare bone cancer that is aggressive, locally invasive, and has a poor prognosis. Chordomas are thought to arise from transformed remnants of notochord and have a predilection for the axial skeleton, with the most common sites being the sacrum, skull base, and spine. The gold standard treatment for chordomas of the mobile filexlib. The radiological differential diagnoses of clivus lesions include chondrosarcoma, fibrous dysplasia, multiple myeloma, and metastatic tumors in addition to chordoma. Chondrosarcoma frequently arises along the petro-occipital fissure and petrous bone, [ 2 , 15 ] and most of the tumors are located laterally in the posterior cranial fossa. Clival chordomas also appear as an extra-axial destructive lesion that primarily involves the bone and have a well-defined appearance with clearly delineated margins. On plain CT scan, chordomas may also have either osteolytic, osteosclerotic, or a mix of these features.
Introduction Clival chordomas present with headache, commonly VI cranial nerve palsy or sometimes with lower cranial nerve involvement. Very rarely, they present with cerebrospinal fluid rhinorrhoea due to an underlying chordoma-induced skull base erosion. Case presentation A 60-year old Caucasian woman presented with meningitis secondary to cerebrospinal fluid rhinorrhoea. At first The rare but correct diagnosis of a clival chordoma which had invaded the brain stem and subsequently hemorrhaged was based on computed tomography and magnetic resonance imaging. The diagnosis was confirmed at surgery when the patient underwent a successful operative decompression of tumor and clot from the pons via a sub-occipital craniotomy.
Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord.The evidence for this is the location of the tumors (along the neuraxis), the similar immunohistochemical staining patterns, and the demonstration that notochordal cells are preferentially left behind in the clivus and sacrococcygeal regions when the remainder of the notochord regresses during
Conventional or Chondroid Chordoma. National Comprehensive Cancer Network (NCCN) guidelines (2020) recommend that all patients with conventional or chondroid chordoma should be evaluated and treated by a multidisciplinary team of doctors who are experts in the management of chordoma. They should undergo the following tests before treatment is
Cureus | Clival Chondroid Chordoma: A Case Report and Review of the Literature Home Journal Back Journal Articles People Posters Specialties Back Specialties Allergy/Immunology Anatomy Anesthesiology Cardiac/Thoracic/Vascular Surgery Cardiology Dentistry Dermatology Emergency Medicine Endocrinology/Diabetes/Metabolism Environmental Health
Clival chordoma tissue obtained at the time of surgical resection ( Figure 1) was implanted in a Matrigel (Corning, Corning, NY) slurry within the epicranial space over the posterior parietal bone and in the subcutaneous space of the flank of nonobese diabetic/severe combined immunodeficiency mice.
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Chordomas are derived from embryonic origin of the remnants of the notochord, specifically between the clivus and sacrum. These tumors most commonly affect th