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It's important that EMLA cream is applied correctly to ensure that it works effectively. It works by numbing the surface of the skin for a short time. This. To apply, squeeze out the prescribed amount of cream directly onto the skin. You can also squeeze it onto a measuring guide to make sure you get the right dose EMLA®. Eutectic Mixture of Local Anaesthetics. Lignocaine and prilocaine Follow all directions given to you by Do not apply EMLA cream to any.Make sure you plan ahead before you use Emla – the cream takes a while to achieve its numbing effect. Put it on about 1 hour before your procedure. Exact Instructions: Apply the cream one hour before your scheduled procedure. The numbing cream will last up to three hours. • Wash your hands. • Open tube (you may The EMLA cream needs to be applied at least 1 hour before a procedure with a needle (taking blood, inserting a cannula), or 2 hours before a surgical procedure patch (EMLA Patch), which has the cream and dressing all ready to use. Follow all directions given to you by your doctor or pharmacist carefully. Step 1 · Ensure that the skin is clean and dry · Press out sufficient quantity of cream onto the site of the procedure · Do not spread out the cream · For needle