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EXCEPTION 3: Other regulations and CMS instructions regarding signatures (such as timeliness standards for particular benefits) take precedence. For medical CMS Medicare Program. Integrity Manual. The Medicare Program Integrity Manual, Chapter 3, explains. Medicare's signature requirements. CMS.gov/ Medicare Program Integrity Manual. Chapter 3 - Verifying Potential Errors and Taking. Corrective Actions. Table of Contents. (Rev. 11529; Issued: 07-28-22). Chapter 1 - Overview of Medical Review (MR) and Benefit Integrity (BI) Programs (PDF) · Chapter 2 - Data Analysis (PDF) · Chapter 3 - Verifying Potential Errors Medicare Program Integrity Manual, Chapter 3,. Section 3.3.2.4. Complying With Medicare Signature Requirements. CMS.gov/Regulations-and-Guidance/Guidance/. Signatures are legible. Reference: CMS “Medicare Program Integrity Manual” (Publication [Pub.] 100-08), Chapter 3, Section 3.4.Medicare Program Integrity Manual. Chapter 3 - Verifying Potential Errors and Taking. Corrective Actions. Table of Contents. (Rev. 367, 02-25-11). 3. Prescription (Order) Requirements. CMS Manual System, Pub. 100-08, Medicare Program Integrity Manual, Chapter 5; Standard Documentation Requirements.