Especially in large-enrollment classes where many undergraduates are first introduced to biology, faculty can use computer-assisted instructional technologies to help gauge student understanding (and misunderstanding) of core science concepts and to better evaluate their own teaching practices. Abstract. Virtual microscopy (VM) uses a computer to view digitized slides and is comparable to using a microscope to view glass slides. This technology has been assessed in human medical education for teaching histology and histopathology, but, to the authors' knowledge, no one has evaluated its use in teaching cytopathology in veterinary taught using the video-assisted instruction and the lecture method in teaching Science and Health. The table also shows the mean difference of 0.50 between the total mean of video-assisted instruction and that of the lecture method. It is to be noted here that the computed mean in the pre-test performance with the video-assisted 1 Bioinformatics Group, Department of Computer Science, Albert-Ludwigs-University Freiburg, Freiburg, Germany. 2 Khoury College of Computer Sciences, Northeastern University, Boston, Massachusetts, United States of America. 3 Institute for Surgical Pathology, Medical Center, University of Freiburg, Freiburg, Germany. ERIC is an online library of education research and information, sponsored by the Institute of Education Sciences (IES) of the U.S. Department of Education. Computer-based instruction, or CBI, is a teaching approach that integrates computer software programs with other teaching materials in the classroom. Other terms used for CBI are: computer-based training, computer-assisted instruction and computer-assisted learning. There are many ways CBI can be used in the They found that the experimental group that took computer-assisted instruction had a better understanding than the control group that was given traditional instruction. Recently, Morgil et al. (2005) compared the traditional and computer-assisted learning in teaching acids and bases. At the end of the study, they found that there was a The effectiveness of computer aided instruction (CAI) was evaluated using a test given before and after the computer module was examined by a group of students. The pre and posttests were identical, and consisted of seven to 1.1ine multiple choice questions, each with five possible answers. All tests were given on the computer. A program use of computer-assisted instruction improves secondary school learners' performance in science. This paper ends with some recommendations for further research. Keywords: computer-assisted instruction, conventional instruction techniques, science, performance, teaching approach Introduction Biology, Chemistry and Physics are the Computer-assisted instruction may be particularly advantageous for certain groups of otherwise disadvantaged students (Cotton, 1991), such as low-achieving students (Edwards et al., 1975; Bangert-Drowns et al., 1985; Roblyer et al., 1988) and economically disadvantaged students (Ragosta et al., 1982). This paper describes a study of the teaching effectienezs of computer-assisted instruction using the PLATO system at the University of Illinois in a first level biology course.. College enrollment, class rank, final grade, and time study data Of the control and experimen