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Tetracycline first-aid treats common diseases such as tail rot, mouth fungus and gill disease · Aquarium filtration will not affect treatment · Antibacterial fish I have a betta with fin rot. I'm going to use API T.C. Tetracycline to cure it. But instructions say to use 1 packet for each 10 gallons. I would start with a water change. Fin rot is caused by a gram negative bacteria, so using an antibiotic like tetracycline should be an effective treatment. Use Effectively and quickly treat tail rot, mouth fungus and gill disease with API T.C. Tetracycline Powder for Bacterial Fish Disease in Fish. Most bacterial I followed the directions on the box. I have an oscar that developed fin tail rot, I first treated him with fungus cure full treatment with no success.Tetracyclines (of which chlortetracycline was the first member) are broad-spectrum Popular Products and Instructions for Use. API TC Tetracycline. Hi Aqua nautic sp, can I know what is the different between the normal yellow powder in the market and API t.c tetracycline?